In the bustling intersection of traditional medicine and cutting-edge technology, a novel approach to treating skin diseases is emerging, one that could reshape the dermatological landscape. Researchers, led by Xinyue Cao from the Department of Rheumatology and Immunology at Nanjing Drum Tower Hospital and the School of Biological Science and Medical Engineering at Southeast University, are exploring the potential of microneedle technology infused with traditional Chinese medicine (TCM). Their findings, published in the journal *Bioactive Materials* (translated as *活性材料*), offer a glimpse into a future where ancient remedies meet modern delivery systems.
Microneedles, tiny structures that painlessly penetrate the skin, are not new. But integrating them with TCM components—flavonoids, saponins, alkaloids, and polysaccharides—presents a unique therapeutic strategy. These natural bioactive compounds, derived from botanical sources, are known for their pharmacological properties. However, their efficacy has often been hindered by poor transdermal permeability and delivery challenges.
“By combining TCM with microneedle technology, we can enhance the permeability of these natural compounds, improve their efficacy, and reduce side effects,” Cao explains. This synergy could revolutionize the treatment of various skin conditions, from inflammatory diseases and hypertrophic scars to wound healing and androgenetic alopecia.
The research categorizes TCM microneedle systems into five types based on their drug delivery mechanisms: solid, coated, hollow, dissolvable, and hydrogel microneedles. Each type offers unique advantages and preparation methods, making them suitable for delivering different TCM components. For instance, dissolvable microneedles can encapsulate hydrophilic drugs, while hydrogel microneedles can provide sustained drug release.
The potential commercial impacts of this research are substantial. The global dermatology market is projected to grow significantly in the coming years, driven by an aging population and increasing prevalence of skin diseases. TCM microneedles could carve out a niche in this market, offering a natural, effective, and patient-friendly treatment option.
However, the path to clinical translation is not without challenges. “While the advantages are unparalleled, we must address issues related to standardization, scalability, and regulatory approval,” Cao notes. These challenges notwithstanding, the research provides a roadmap for developing TCM microneedles with optimized structures and functions.
As the field evolves, interdisciplinary collaboration will be key. Researchers, clinicians, and industry stakeholders must work together to harness the full potential of TCM microneedles. The journey is just beginning, but the destination—a future where ancient wisdom and modern technology converge to treat skin diseases—is within sight.
In the words of Cao, “This review aims to facilitate the development of TCM microneedles and provide insightful information for researchers in the field.” With each step forward, the promise of TCM microneedles becomes clearer, offering hope for a new era in dermatological treatment.